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Adjunctive Modafinil at Initiation of Treatment with a Selective Serotonin Reuptake Inhibitor Enhances the Degree and Onset of Therapeutic Effects in Patients with Major Depressive Disorder and Fatigue
ABSTRACT BACKGROUND: Benefit from selective serotonin reuptake inhibitor (SSRI) treatment in major depressive disorder (MDD) usually takes…
February 20, 2023
Modafinil vs. Caffeine: Effects on Fatigue During Sleep Deprivation
ABSTRACT INTRODUCTION: The extent to which modafinil and caffeine reverse fatigue effects (defined as performance decrements with…
February 2, 2023
Effect of Modafinil on Cerebral Blood Flow in Narcolepsy Patients
ABSTRACT BACKGROUND: To investigate the effects of modafinil on regional cerebral blood flow (rCBF) in narcolepsy, we…
February 20, 2023
Clinical Pharmacokinetic Profile of Modafinil
ABSTRACT Aodafinil is a unique wake-promoting agent for oral administration. Its pharmacological properties are distinct from those…
February 20, 2023
Modafinil for the Treatment of Excessive Daytime Sleepiness in Parkinson’s Disease: A Case Report
ABSTRACT We report a 59 year old woman with levodopa responsive Parkinson’s disease who developed excessive daytime…
February 2, 2023
Orexin Peptides Prevent Cataplexy and Improve Wakefulness in an Orexin Neuron-Ablated Model of Narcolepsy in Mice
ABSTRACT Narcolepsy-cataplexy is a neurological disorder associated with the inability to maintain wakefulness and abnormal intrusions of…
February 2, 2023
A Commentary on the Neurobiology of the Hypocretin/Orexin System
ABSTRACT Hypocretins/orexins are rapidly emerging as functionally important neurotransmitters. Two related neuropeptides (Hcrt-1/OXA, Hcrt-2/OXB) encoded by the…
February 20, 2023
Modafinil More Effectively Induces Wakefulness in Orexin-Null Mice Than in Wild-Type Littermates
ABSTRACT Narcolepsy-cataplexy, a disorder of excessive sleepiness and abnormalities of rapid eye movement (REM) sleep, results from…
February 20, 2023
Dosing Regimen Effects of Modafinil for Improving Daytime Wakefulness in Patients With Narcolepsy
ABSTRACT SUMMARY: In a multicenter, randomized, double-blind study the authors compared the efficacy of modafinil 400 mg…
February 2, 2023
Pharmacological Aspects of Human and Canine Narcolepsy
ABSTRACT Narcolepsy-cataplexy is a disabling neurological disorder that affects 1/2000 individuals. The main clinical features of narcolepsy,…
February 20, 2023