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Modulation of the Acoustic Startle Response by the Level of Arousal: Comparison of Clonidine and Modafinil in Healthy Volunteers
ABSTRACT A sudden loud sound evokes an electromyographic (EMG) response from the orbicularis oculi muscle in humans…
February 20, 2023
An Open-Label Study of Adjunctive Modafinil in Patients with Sedation Related to Serotonergic Antidepressant Therapy
ABSTRACT OBJECTIVE: In patients with major depressive disorder (MDD), excessive sleepiness and fatigue not only are major…
February 20, 2023
Depression-Like Deficits in Rats Improved by Subchronic Modafinil
ABSTRACT RATIONALE: Attentional and sensorimotor gating deficits in human depression are observed as residual symptoms irrespective of…
February 20, 2023
Efficacy and Safety of Modafinil Film-Coated Tablets in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: Results of a Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose Study
ABSTRACT OBJECTIVE: Modafinil, which is structurally and pharmacologically different from other agents that are used for the…
February 2, 2023
Retrospective Review of Modafinil Use for Cerebral Palsy
ABSTRACT A retrospective review was undertaken at Texas Tech University Health Sciences Center regarding the use of…
February 20, 2023
Amplification of Cortical Serotonin Release: a Further Neurochemical Action of the Vigilance-Promoting Drug Modafinil
ABSTRACT The present in vitro and in vivo studies examined the effects of modafinil on serotonergic transmission…
February 2, 2023
Armodafinil, the R-Enantiomer of Modafinil: Wake-Promoting Effects and Pharmacokinetic Profile in the Rat
ABSTRACT Modafinil reduces the excessive sleepiness associated with narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep…
February 2, 2023
Neuroprotective Effects of Modafinil in a Marmoset Parkinson Model: Behavioral and Neurochemical Aspects
ABSTRACT The vigilance-enhancing agent modafinil has neuroprotective properties: it prevents striatal ischemic injury, nigrostriatal pathway deterioration after…
February 20, 2023
Modafinil Affects Mood, But Not Cognitive Function, in Healthy Young Volunteers
ABSTRACT Modafinil is a selective wakefulness-promoting agent with beneficial effects in narcolepsy and conditions of sleep deprivation….
February 2, 2023
Steady-State Pharmacokinetics and Tolerability of Modafinil Given Alone or in Combination with Methylphenidate in Healthy Volunteers
ABSTRACT The potential for a pharmacokinetic (PK) drug-drug interaction between modafinil and methylphenidate, each at steady state,…
February 20, 2023