Modafinil and cocaine interactions

Malcolm R, Swayngim K, Donovan JL, Devane CL,
Elkashef A, Chiang N, Khan R, Mojsiak J,
Myrick DL, Hedden S, Cochran K, Woolson RF.
Center for Drug and Alcohol Programs,
Department of Psychiatry and Behavioral Sciences,
Medical University of South Carolina (MUSC),
Charleston, South Carolina, USA.
Am J Drug Alcohol Abuse. 2006;32(4):577-87.

This Phase I trial evaluated the interaction between modafinil steady-state and cocaine. Twelve non-treatment seeking, cocaine dependent volunteers received four sets of randomized blinded infusions of saline, 20 mg IV cocaine, and 40 mg IV cocaine. Modafinil was given open label at 0 mg, 400 mg, or 800 mg. Modafinil combined with IV cocaine did not result in any significant hemodynamic interactions. Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted.

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